| abstract |
PURPOSE: To provide a percutaneous administration preparation capable of being applied not only to an attached site but also to all body while controlling the absorption of a drug, by solidifying an alcoholic aqueous solution having good percutaneous absorbability in a matrix state. n CONSTITUTION: A systemic percutaneous administration preparation comprises a solid product produced by gelling a solution comprising 10-60wt.% of a lower alcohol, 2-40wt.% of water, 20-70wt.% of a glycol, 0.1-10wt.% of a percutaneous absorption-accelerating agent, 1-5wt.% of a water-soluble polymer and a drug ingredient with 1-5wt.% of dibenzylidene sorbitol or 3-15wt.% of a metal soap. The percutaneous absorption-accelerating agent includes polyhydric alcohol fatty acid esters, higher alcohols, higher fatty acids, terpenes, essential oils and AZONE. A means for bringing the preparation into contact with the skin of a man or animal is disposed in the preparation so that the exposed surface of the solidified gel is brought into contact with the skin, if necessary, through a percutaneous absorption-controlling membrane without exposing to air and so that the evaporation of the solvent is prevented. n COPYRIGHT: (C)1992,JPO&Japio |