| abstract |
PURPOSE: To provide a new compound effectively used as immunosuppressive agent, antibiotics, or the like. n CONSTITUTION: This compound is represented by formula I [R 1 is H, OH, alkoxy or the like; R 2 is H; R 3 is O, or (H, OH); R 4 is CH 3 , C 2 H 5 , allyl or the like; R 5 is OH, alkoxy, or the like; R 6 is OH; R 7 is OH, alkoxy, NR 8 R 9 (R 8 and R 9 are each H, alkyl, aryl); further R 1 and R 2 may together represent a second bond between carbon atoms to which they are attached], and pharmaceutically acceptable salts thereof, e.g. methyl-12-allyl-4,6-dimethoxy-19-[4- hydroxy-3-methoxycyclohexyl]-13-oxo-2,8,10,16,18-pentamethyl-5,15,17-trihydroxy- nonadeca-10,18-dienoate. The compound is formed by reducing a compound of formula II (R 10 is O) in the presence of amine or acid addition salt thereof. n COPYRIGHT: (C)1992,JPO |