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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42
filingDate 1990-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d33551f9d95c95b2b62aa4df9ade1fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4fc7579efa307f3b3198e224832796e5
publicationDate 1992-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H0421669-A
titleOfInvention 3-carbomethoxyindole derivative and its production
abstract NEW MATERIAL:A 3-carbomethoxyindole derivative expressed by formula I (R 1 is hydroxy or lower alkoxy; R 2 is H or amino-protecting group) and salts thereof. n EXAMPLE: 1-Carbobenzoxy-3-carbomethoxyindole. n USE: Useful as an intermediate for medicines, agricultural chemicals and fine chemicals, especially as an intermediate for CC-1065, etc., having a structure effectively used as, e.g. a carcinostatic agent. n PREPARATION: A phenylhydroxylamine derivative expressed by formula II (R 3 is H, hydroxy or lower alkoxy; R 4 is amino-protecting group) is allowed to react with methyl propiolate in the presence of a base in an organic solvent such as benzene, preferably at 15-30°C to afford the objective compound expressed by formula III in formula I. The mixing ratio of the compound expressed by formula II to the methyl propiolate is preferably within the range of (1:1) to (1:5). n COPYRIGHT: (C)1992,JPO&Japio
priorityDate 1990-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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