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filingDate 1990-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_128a4d4eb0d11843aca3a5eac8edc17b
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publicationDate 1992-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H0421646-A
titleOfInvention Preparation of chloroethyl ether
abstract PURPOSE: To prepare the subject compound in a high yield under a relatively mild condition by employing an N-substituted cyclic amide or N-substituted urea as a catalyst when a hydroxyethyl ether is made to react with thionyl chloride to prepare the subject compound. n CONSTITUTION: A compound of formula (R is alkyl or aryl which can have substituents, respectively) is allowed to react with thionyl chloride in the presence of an N-substituted cyclic amide [especially having amide bonds of formula II or III (R 1 is hydrocarbon group)] or an N-substituted urea such as N,N- dimethylimidazolidinone, N-methylpyrrolidone or N,N'-diphenyl urea preferably at 40-150°C, especially at 50-90°C, to prepare the objective compound of formula useful as an intermediate for drugs, agricultural chemicals, pigments, etc., under a relatively mild condition in a high yield, while reducing the production of 1,2-dichloroethane (by-product to below 1%. n COPYRIGHT: (C)1992,JPO&Japio
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006064897-A1
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