| abstract |
PURPOSE: To provide the title novel derivative useful for the prevention and therapy of human and mammalian peptic ulcer. n CONSTITUTION: The objective compound of formula I [R 1 is alkoxy, halogen, alkyl, alkylthio, alkanoyloxyalkyl, etc.; R 2 and R 3 are each H, alkyl, cycloalkyl, alkenyloxy, alkenyl, phenylalkyl, alkynyl, etc.; R 4 is phenyl which may have one or two substituents (alkyl, halogen, alkoxy, phenyl, CN, OH< etc.), tetrahydronaphthyl or naphthyl; n is 0-2] or its salt. For example, N-2- propenyl-4-[(2-ethylphenyl) amino]-8-methoxyquinoline-3-carboxamide hydrochloride. The present compound can be obtained by the following process: a compound of formula II is reacted with a halogenating agent into a compound of formula III (X is halogen), which is then successively reacted with amines of respective formulas HNR 2 R 3 and H 2 N-R 4 . n COPYRIGHT: (C)1992,JPO&Japio |