| abstract |
PURPOSE: To obtain a new oxazole compound having bone amount reduction- suppressing action and bone amount-increasing action as well as low toxicity. n CONSTITUTION: The objective oxazole compound expressed by formula I [A is -CH 2 OR 2 (R 2 is H, hydrocarbon residue, heterocyclic ring or acyl) or aldehyde; B is phenyl; R 2 is H or alkyl; n is integer of 0-6, provided that when n=2, R 1 is alkyl] or salt thereof, e.g. 4-(3,5-ditrifluoromethylphenyl)-2-oxazole propionic acid ethyl ester. A compound expressed by the formula I-1 wherein A is COOR 6 (R 6 is alkyl or aralkyl) in the compound expressed by formula I is obtained by reacting a compound expressed by formula II or salt thereof with a dicarboxylic acid monoamide expressed by formula III. n COPYRIGHT: (C)1992,JPO&Japio |