http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H04200391-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33dafb5bbc2ec47ebcb7becbbe60f704 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate | 1990-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3e6be58cbaee827be0a4e4794dbe9ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5290ad7094ff87c892ad90ea3cf42935 |
| publicationDate | 1992-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H04200391-A |
| titleOfInvention | Production (r)-2-hydroxy-4-phenylbutyric acid |
| abstract | PURPOSE: To produce the subject compound in high purity and efficiency by reacting racemic 2-hydroxy-4-phenylbutyric acid (HPB) with a carboxylic acid anhydride, etc., in the presence of a specific enzyme. n CONSTITUTION: Racemic HPB (A) is charged in an amount of 0.5-50wt.% to an organic solvent such as toluene to obtain a reaction liquid (B). A carboxylic acid anhydride such as acetic anhydride is added to the liquid B in an amount of 0.5-10 equivalent based on the component A. A reaction mixture (C) is produced by adding 0.1-5 pts.wt. (based on 1 pt.wt. of the component A) of a lipase produced by a microorganism belonging to genus Pseudomonas. The component C is made to react at 5-50°C to effect the acylation of (S)-HPB and obtain a reaction product (D). The objective (R)-2-hydroxy-4-phenylbutyric acid is produced by filtering the component D to remove insoluble materials, distilling out the reaction solvent and purifying the residue by column chromatography, etc. n COPYRIGHT: (C)1992,JPO&Japio |
| priorityDate | 1990-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.