| abstract |
NEW MATERIAL:A compound expressed by formula I (B is nucleic acid base derivative; R is H, acyl or phosphate group or protecting group). n EXAMPLE: (±)-9-(1,6-Dihydroxy-3-hexyl)adenine. n USE: An antiviral agent and anticancer agent. n PREPARATION: A compound expressed by formula II (X is eliminating group) is reacted with a nucleic acid base derivative (e.g. adenine) as necessary in the presence of a base catalyst (e.g. potassium carbonate), in a solvent such as DMF at 0°C to temperature capable of refluxing the solvent to afford a compound expressed by formula III (B 1 is nucleic acid base derivative which may be protected). Then, as necessary, a protecting group thereof is removed or replaced by other protecting group to provide the compound expressed by formula I. n COPYRIGHT: (C)1992,JPO&Japio |