| abstract |
PURPOSE: To provide the subject composition containing a peptide-type medicine such as calcitonin and insulin and natural bile extract powder, having high absorbability, giving little irritation to mucosa and having high safety. n CONSTITUTION: The subject composition contains a peptide-type medicine and natural bile extract powder (e.g. bile powder, ox bile extract powder, concentrated ox bile, ox bile, liver extract powder and bile extract). The bile extract powder has remarkable absorption promoting effect on the hardly absorbable peptidetype medicine in transmucous administration and gives little irritation to the mucosa. The bile extract powder may be used singly or as a mixture with a surfactant and its amount is preferably 0.1-10mg per unit body weight. It can be prepared in any dosage form suitable for transmucous administration, e.g. tablet, powder, liquid, suppository, ointment or troche. It is absorbed through mucous membrane of nose, oral cavity, rectum, eye, vagina, digestive tracts, etc. n COPYRIGHT: (C)1992,JPO&Japio |