| abstract |
PURPOSE: To obtain an optically active carboxylic acid through the action of specified microorganisms or a processed product thereof on the nitride or amide of a specific racemate. n CONSTITUTION: The nitride or amide of a recemate of formula I is subjected to the action of microorganisms belonging to the genus Alcaligenes, Peseudomonas, Rhodopseudomanas, Corynebacterium, Acinetobacter, Bacillus, Mycobacterium, Rhodococcus, Nocardia, Arthrobacter, Moraxella, Klebsiella, Acremonium or Candida or a processed product thereof to prepare an optically active carboxylic acid of formula II or an optically active nitrile or amide of formula III wherein X is nitrile or amide group; R 1 is aryl, aryloxy, cycloalkyl, heterocyclic group; R 2 is halogen, hydroxy, alkyl; n is 1-3. n COPYRIGHT: (C)1992,JPO&Japio |