| abstract |
NEW MATERIAL:The compound of formula I (R 1 is H, lower alkyl, lower alkoxy or halogen; R 2 is 1,2-dihydro-2-oxo-1,8-naphthyridin-1-yl or 1,2-dihydro-2- thioxo-1,8-naphthyridin-1-yl). n EXAMPLE: 1-(3-Pyridyl)-1,8-naphthyridin-2(1H)-one. n USE: An antiulcer agent having acid secretion inhibiting action and mucosa protecting action. n PREPARATION: The objective compound can be produced by reacting an aldehyde of formula II (X is halogen) (e.g. 2-chloronicotin-aldehyde) with a 2-[bis(2,2,2-trifluoroethoxy)phosphono]acetic acid lower alkyl ester of formula III, etc., under basic condition and condensing the resultant α,β-unsaturated carboxylic acid ester of formula IV with an aminopyridine of formula V under basic condition. n COPYRIGHT: (C)1992,JPO&Japio |