http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H041136-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c62268de3e92657ca5b9adcac4778225 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1990-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88c468285a117a5052ff49f473db8d98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b839d0fad2f7360a47b3005f660b561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1692767f4fb90dd33d2e7ca1a636b1c7 |
| publicationDate | 1992-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H041136-A |
| titleOfInvention | Complex antitumor agent |
| abstract | PURPOSE: To provide a complex antitumor agent containing lymphotoxin and a guanosine 3',5'-cyclic monophosphate (cyclic GMP) derivative and exhibiting extremely excellent antitumor activity. n CONSTITUTION: The objective agent contains (A) lymphotoxin, preferably a gene recombinant lymphotoxin having the amino acid sequence of formula and (B) a cyclic GMP derivative, e.g. a cell membrane permeable dibutyryl cyclic GMP or bromocyclic GMP, or a substance having cyclic GMP inducing property such as NO derivative (e.g. sodium nitroprusside or nitroglycerin), a phosphodiesterase inhibitor (e.g. isobutylmethylxanthine or theophylline) or a phosphorylase AZ activator (e.g. transducin of GTP-bonded protein). The amount of the component B is preferably 1μM to 1M based on 1mg of the component A. n COPYRIGHT: (C)1992,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006290440-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H07331783-A |
| priorityDate | 1990-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.