| abstract |
NEW MATERIAL: A compound of the formula (the dotted line indicates the 4,5-unsaturated of the 4,5-dihydrofuranone ring; R 1 and R 2 are each H, thienyl, furanyl, phenyl, etc.; R 3 -R 5 are each H, a halogen, CF 3 NO 2 an alkyl, an alkyl or alkylene bridge between R 4 and R 5 or R 3 and the ring N, benzyl, phenyl, etc.; R 6 in the dihydrofuranon series is H or an alkyl) or its salt. n EXAMPLE: 5-[1-(2-Ethylimidazole)methyl]-4,5-dihydro-3,3-diphenyl-2(3H)furanone. n USE: Antagonist of cholinergic receptors useful as anti-neurogenic bladder disorder agent, anticonvulsant, antisecretory agent or mydriatic agent. n PROCESS: For example, diphenylacetic acid is subjected to dilithium salt formation and treated with allyl bromide to give 2,2-diphenyl-4-pentenoic acid. The sodium salt of the product is treated with bromine to form a cyclic furanone, which is then reacted with a substd. imidazole under heating to give the compound of the formula. n COPYRIGHT: (C)1992,JPO |