| abstract |
NEW MATERIAL:A compound shown by formula I [R 1 is ≥2C alkyl, aryl, substituted aryl, heteroaryl or (substituted) heteroaryl; R 2 is group shown by formula V (R 3 and R 4 are H, alkyl, cycloalkyl, aryl, or substituted aryl) or group shown by formula VI (X is direct bond, C, O or N); with the proviso that a case wherein combinations of R 3 and R 4 are H and ≤3C alkyl is omitted] and a salt thereof. n EXAMPLE: N-[3-(3,4-Dinicotinoyloxyphenyl)-propionyl]-morpholine. n USE: A medicine. A medicine for preventing development of central nervous system repressing diseases and therapeutic agent for the diseases. Having inducing action on production and secretion of nerve growth factor in a specific tissue in the brain. n PREPARATION: For example, a compound shown by formula II is esterified with an acid halide shown by formula III (Y is Cl or Br) or an acid anhydride shown by formula IV in a solvent such as chloroform in the presence of a base such as triethylamine at 0-50°C by a conventional procedure to give a compound shown by formula I. n COPYRIGHT: (C)1991,JPO&Japio |