| abstract |
NEW MATERIAL: A compound of formula I [R 1 is CO 2 R 4 (R 4 is H, chain C 1-6 alkyl or the like), NHSO 2 CF 3 or the like; R 2a , R 2b are H, NH 2 or the like; R 3a is H, halo or the like; R 3b is H, NO 2 or the like, R 6 is halo, CF 3 or the like; E is single bond, CO or the like, X does not exist, or is O or the like; -A-B-C-D is connected with imidazole and is constitutive atom of 6 membered optionally saturated heterocycle including 1-3N atoms]. n EXAMPLE: 2-Butyl-3-(2'-carboxybiphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine. n USE: Angiotensin II antagonist useful in the treatment of hypertension, etc. n PROCESS: The treatment is performed by a compound of formula MH (M is Na, Li or the like) in DMF anhydride of heterocycle of formula II, to obtain alkali metal salt, and then the same is dissolved in bipolar aprotic solvent such as DMF or the like, and is alkylated by using a compound of formula III (Q is halo, -O-tosyl or the like). n COPYRIGHT: (C)1991,JPO |