| abstract |
NEW MATERIAL: A compound of formula I (R 1 is an amino having antibacterial activity; R 2 is H, a lower alkoxy, a lower alkylthio, etc.; R 3 is H or an organic group bonded via C, O, S or N; R 4 is an electronegative acidic group, or R 3 and R 4 together form a heterocyclic ring; R 5 is H, a lower alkyl, etc.) and its ester, salt, and hydrate. n EXAMPLE: [2S-(2α,5α,6β)]-6-[[[4-[1-ethyl-6-fluoro-1,4-dihydro-3-(methoxycarbonyl)-4- oxo-7quinolinyl]-1-piperazinyl]methylene]amino]-3,3-dimethyl-6-oxo-4-thia-1- azabicyclo[3,2,0]heptane-2-carboxylic acid. n USE: Treatment or prophylaxis of infectious diseases. n PROCESS: The compound of formula I can be obtained by reacting a compound of formula II or its ester with an acetal of formula R 1 -R b (R b is an acetal functional group) or its ester. n COPYRIGHT: (C)1991,JPO |