| abstract |
NEW MATERIAL:A compound expressed by formula I {R 1 and R 2 are H or lower alkyl; R 3 is (substituted) aryl or heterocyclic ring; R 4 is H, halogen or lower alkyl; A is methylene, methine, oxa, thia, sulfinyl or sulfonyl; Y is vinylene or ethylene; Z is expressed by formula II or formula III [R 5 is (protected) carboxy; R 6 is H or OH protecting group]; dotted line is single bond or double bond}. n EXAMPLE: (±)-Erythro-(E)-7-[5,6-dihydro-4,4-dimethyl-1-(4-fluorophenyl)-4H- pyrrolo[3,2,1-ij]quinoline-2-yl]-3,5-dihydroxyhepto-6-enic acid. n USE: Inhibitor of 3-hydroxy-3-methylglutaryl.coenzyme-A reductase. n PREPARATION: A compound expressed by formula IV or salt of said compound is reduced to afford a compound expressed by formula V. n COPYRIGHT: (C)1991,JPO&Japio |