| abstract |
PURPOSE: To obtain an antitumor agent, containing a 2'-deoxy-5- trifluoromethyluridine derivative and 3'-azido-3'-deoxythymidine derivative, etc., and remarkably improved in antitumor and antiviral effects. n CONSTITUTION: An antitumor agent containing a compound expressed by formula I [R 1 and R 2 are H or C(=O)R 3 (R 3 is 1-19C alkyl, etc.] and a compound expressed by formula II (R 8 is H, lower alkyl, benzyl, etc.) or a 3'-substituted triazole-3'-deoxythymidine derivative expressed by formula III (R 9 and R 10 are H, lower alkyl or lower alkoxycarbonyl). The compound expressed by formula II or III is used in an amount of preferably ≥0.5mol, especially preferably ≥0.5mol and ≤100mol based on 1mol compound expressed by formula I together. n COPYRIGHT: (C)1991,JPO&Japio |