| abstract |
NEW MATERIAL:A compound expressed by formula I {R 1 is H, 1-8C alkyl, carboxy-1-4C alkyl, etc.; R 2 is formula II [R 3 is (1-3C alkyl or halogen- substituted) thienyl, furyl, pyrrolyl (N is substituted with carboxy-1-3C alkyl), etc.], formula III ((m) is 0 or 1), formula IV [R is 1-3C alkyl; R 4 is phenyl (substituted with the same substituent group as that defined in R 3 )} and salts thereof. n EXAMPLE: N-[2-(4-Oxo-2-thioxo-5-thiazolidinylidene)propionyl]anthranilic acid. n USE: A medicine, having aldose reductase inhibitory action and useful for preventing and treating diabetic complications, such as retinopathy, cataract, neuropathy or renopathy. n PREPARATION: Rhodanine expressed by formula V is reacted with an aldehyde or ketone expressed by formula VI preferably in a solvent, such as toluene, preferably in the presence of a catalyst, such as ammonium acetate, to afford the compound expressed by formula I. n COPYRIGHT: (C)1991,JPO&Japio |