http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0366664-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33dafb5bbc2ec47ebcb7becbbe60f704 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| filingDate | 1989-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d917b46fcd34d71ceb83d96f4a40ca5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d4d4dbf7f829acc1a139e343f9a9fa7 |
| publicationDate | 1991-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0366664-A |
| titleOfInvention | Production of optically active beta-hydroxy thioester |
| abstract | PURPOSE: To obtain a compound useful as a synthetic intermediate for various natural products, medicines, etc., in high optical purity and yield by reacting an aldehyde with a silyl enol ether in the presence of an optically active diamine and a tin reagent. n CONSTITUTION: An aldehyde expressed by the formula R 1 CHO (R 1 is alkyl, cycloalkyl, aralkyl or aryl) is reacted with a silyl enol ether expressed by formula I (R 2 and R 4 are alkyl; R 3 is H or alkyl) in the presence of an optically active diamine and a tin reagent in a solvent, such as dichloromethane, at -100 to -30°C to afford a compound expressed by formula II (* indicates asymmetric carbon). 1-Methyl-2-(1-piperidinylmethyl)pyrrolidine is preferably used as the diamine and a combination of tin (II) triflate with tributyltin fluoride is preferably used as the tin reagent. n COPYRIGHT: (C)1991,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4958906-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8333841-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2008018297-A1 |
| priorityDate | 1989-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.