abstract |
NEW MATERIAL:Erithropoietin modified with polymeric compound. n USE: Used as medicine for various anemia such as renal anemia according to decrease of erithropoietin production owing to renal injury continuously exhibiting erithropoietic activity. n PREPARATION: By gene technological method, gene-recombinant erithropoietin produced in CHO cell is added to a solution adjusted of dextran 40, etc., and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloric acid, etc., is added, then subjected to coupling. Besides, the polymeric compound is preferably dextran, polyethylene glycol or amino acid polymer. n COPYRIGHT: (C)1991,JPO&Japio |