http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0363272-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02 |
| filingDate | 1990-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aab8dbd36595c36807a1806fe96b1a64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cefa76c583ea550eef356ab2a54d792 |
| publicationDate | 1991-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0363272-A |
| titleOfInvention | Resolution of 1-azabicyclo(2,2,1)heptane-3-carboxylate |
| abstract | PURPOSE: To easily obtain a substantially pure enantiomer of the subject compound, by producing diastereomers by substituting OH of carboxy with an asymmetrical amine or the like, separating and obtaining a substantially pure diastereomer, and then hydrolyzing the same. n CONSTITUTION: A diastereomer in which OH of carboxy of formula I (R, R 1 -R 3 are each H, an alkyl, an aryl, an aralkyl or the like; R 1 ≠R 2 ≠R 3 ; Y is a Lewis acid having p orbital forming a stable complex with lone electron-pair or ring N) is substituted with an asymmetrical amine or the residue of an α-amino acid, is prepared, then is separated to obtain a substantially pure diastereomer of the derivative, and is hydrolyzed to separate a substantially pure enantiomer of formula II ((x) is 0 or 1; (y) is 1 or 2; x+y<3; exo form, end form or a mixture of these), which is useful as an intermediate for synthesis of oxidiazoles having muscarine agonist activity, by crystallization or the like. n COPYRIGHT: (C)1991,JPO |
| priorityDate | 1989-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.