http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0358989-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e45efeaa6a34dfd9d44fa29a7fe0c806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b65747ed78f05dd9ebe107b50ce2855 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1989-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_617d6377b8e3cb4514dae2390196c7d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddb8f2e6765feb3014a8e2a334db1735 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6902729379209d29154b51d5008671bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b12de5d9e74956870b48df8840be85d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4924c548052e7ce45195967bf02409d |
| publicationDate | 1991-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0358989-A |
| titleOfInvention | Oxazoloquinazoline compound |
| abstract | NEW MATERIAL:A compound expressed by formula I (double lines of dotted line and solid line are single bond or double bond; in a case of single bond, R 1 is H or lower alkyl, etc.; R 2 to R 4 are H or OH, etc.; n is 1-3). n EXAMPLE: Cis-10-Benzyl-1,3,4,5,10,10a-hexahydro-5-(3,4,5-trimethoxyphenyl)-7,8- methylene dioxyoxazolo[4,3-b]quinazolin-3-one. n USE: Used as anti-tumor agent having strong anti-tumor activity and low toxicity. n PREPARATION: At first, N-protected aniline compound expressed by formula II is reacted with aromatic aldehyde expressed by formula III to obtain a compound expressed by formula IV and resultant compound is reacted with carbamic acid alkyl ester. Then, said reaction product is reacted with glyoxylic acid, thus reduced to obtain a compound expressed by formula V. Finally, resultant compound is treated with base to obtain a compound expressed by formula VI and said compound is de-protected by hydrogenating decomposition reaction to afford the aimed compound of cis-form in which R 1 is H. n COPYRIGHT: (C)1991,JPO&Japio |
| priorityDate | 1989-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID409092530 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID760 |
Total number of triples: 19.