http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H035464-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d78cd2835221849f6a74e6349185819 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 |
| filingDate | 1990-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c628c1af713df14ccb6f2f06eed504d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e8ba5876fc5f80215fb630d84003db5 |
| publicationDate | 1991-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H035464-A |
| titleOfInvention | Benzimidazole derivative, preparation thereof, pharmaceutical composition for treating hypertension and congestive heat failure, and intermediate |
| abstract | NEW MATERIAL: A compound of formula I (wherein R 1 is a 1-8C alkyl, phenyl, etc.; R 2 -R 4 are each H, a 1-4C alkyl, a halogen, NO 2 , CF 3 , etc.; X is a single bond, phenylene, etc.; Z is 1H-tetrazol-5-yl or formula II-III; R 5 is H or a nontoxic biodegradable group such as a physiologically acceptable alcohol; and R 6 is a 1-6C alkyl, phenyl, etc.), or a physiologically acceptable salt thereof except when R 5 is other than H. n EXAMPLE: 4[(2-Butyl-1H-benzimidazol-1-yl)methyl]-N-phenylsufonylbenzamide. n USE: A remedy for hypertension, congestive heart failure, aldosteronism or other diseases or symptoms in which the renin-angiotensin-aldosterone system plays are remarkable causative role. n PREPARATION: Q of a compound of formula IV (wherein Q is protected COOH) is converted into COOH, and the resulting compound is optionally reacted with a compound of formula; NH 2 SO 2 R 6 or R 5 OH to obtain the compound of the formula I (wherein Z is formula II or III). n COPYRIGHT: (C)1991,JPO |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9204343-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008514704-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015518863-A |
| priorityDate | 1989-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.