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filingDate 1989-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1991-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H0349687-A
titleOfInvention Novel antitumor antibiotic resorthiomycin and its preparation
abstract PURPOSE: To prepare resorthiomycin having an antitumor property by culturing a resorthiomycin-producing bacterium belonging to the genus Streptomycin in a medium containing nutritive sources. n CONSTITUTION: Streptomyces collinus 45H-6 strain (FERM 10753) separated from a soil collected in Isehara city, Kanagawa prefecture has the following mycological properties. Figure: forms aerial mycelium and produces spores each having a size of 0.5-0.9× 0.8-1.0μm; excellently grows in a starch-inorganic salt agar medium; liquidizes gelatin; utilizes glucose and does not utilize sucrose; growth temperature: 20-40°C, etc. The bacterium is cultured in a medium containing peptone, sucrose, NaCl, etc. The cultured product is subjected to an extraction and purification treatment using a solvent extraction method, an ion exchange resin method, etc., to prepare an antitumor antibiotic, resorthiomycin of the formula or a salt thereof. n COPYRIGHT: (C)1991,JPO&Japio
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