| abstract |
PURPOSE: To provide the subject topically administrable preparation containing a specific methanediphosphonic acid deriv. and useful for treating hypercalcemia and an osteolytic bone transfer disease and easily carried via the skin to immediately act on the whole body. n CONSTITUTION: The objective preparation pref. contains 0.5-5% of a methanediphosphonic acid deriv. represented by the formula (wherein R 1 and R 2 are each H or 1-3C alkyl) and its salt (e.g.; 3-amino-1-hydroxypropane-1,1- diphosphonic acid). This preparation is pref. used in a form of cream, gel, an ointment, lotion, paste, froth, tinctura, a microemulsion or a soln. n COPYRIGHT: (C)1991,JPO |