abstract |
PURPOSE: To obtain the title new copolymer suitable as a material such as artificial blood vessel, having excellent bioavailability, mechanical strength and moldability by copolymerizing methacryloyloxyethylphosphorylcholine with a methacrylic acid ester. n CONSTITUTION: 2-Methacryloyloxyethylphosphorylcholine(MPC) is copolymerized with a methacrylic acid ester to give the aimed copolymer having a repeating unit shown by the formula [a is 0.03-0.7; b is 0.3-0.97; n is ≥2; R is H or OR' (R' is aliphatic hydrocarbon; aromatic hydrocarbon)] and ≥5,000 molecular weight. MPC, for example, is obtained by reacting 2-bromoethylphosphoryl dichloride with hydroxyethyl methacrylate and reacting the prepared 2- methacryloyloxyethyl 2'-bromoethyl phosphate with trimethylamine in a methanol solution. n COPYRIGHT: (C)1991,JPO&Japio |