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filingDate 1989-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52365669fec277e601bcc98a0e77ba97
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publicationDate 1991-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H0339095-A
titleOfInvention Production of optically active nitrile compound
abstract PURPOSE: To make it possible to directly obtain the title compound in mild conditions by reacting a specific compound with a microbial cell (treated material) of microorganism of the genus Nocardia having nitrile hydrolyzing ability. n CONSTITUTION: A microbial strain of Nocardia sp. PA-34, etc., having nitrile hydrolyzing ability is aerobically cultured in a culture medium containing a nitrile compound which is a derived substrate such as propionitrile, glucose, etc., and urea, etc., to afford a microbial cell cultured material (A). Then a racemic nitrile compound (B) such as 2-methylbutane nitrile expressed by the formula (R 1 and R 2 are alkyl which may have mutually different substituent groups; n is 0 or 1) is reacted with the ingredient A at 20-50°C and pH14-13 for 1-15 day to provide a reaction product (C). Then the C ingredient is separated and purified by phase separation, column chromatography, etc., to produce the optically active nitrile compound corresponding to the ingredient B. n COPYRIGHT: (C)1991,JPO&Japio
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009047924-A1
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