| abstract |
NEW MATERIAL: 3-Carbalkoxyamino-5-aminoacyl-5-H-dibenz[b,f]azepine derivatives of formula I (R 1 is linear or branched alkyl; R 2 is H or 1-6C alkyl which can be linear, branched, or cyclized, or aralkyl such as benzyl, or phenylethyl, or β-oxyethyl; n is 1-5; X is -CH 2 -CH 2 -, -CH=CH-; or when R 1 is methyl or isopropyl, or n is 2-5, R 2 is methyl) and their salts. n EXAMPLE: 3-Carboethoxyamino-5-benzylaminoacetyl-10,11-dihydro-5H-dibenz(b,f) azepine. n USE: Having antiarrhythmia effect and useful for treatment of cardiac dysrhythmia. n PROCESS: A compound of formula II is substituted with an amine of formula III to obtain a compound of formula I. n COPYRIGHT: (C)1991,JPO |