| abstract |
NEW MATERIAL:The compound of formula I (A is S, O, CH 2 , NR 6 or CO; R 1 is R, alkyl, aralkyl, aryl or amino protecting group; R2 is alkyl, cycloalkyl, alkoxy, aryl, etc.; R 3 and R 4 are H, alkyl or aralkyl; R 5 is H, halogen, alkyl or alkoxy; R 6 is R 1 excluding aryl) and its various isomers. n EXAMPLE: cis-3-tert-Butoxycarboxamido-4-(1-methyl-4-imidazolyl)-2-oxo-2,3,4,5 tetrahydro-1H-1-benzazepine-1-acetamide. n USE: A cerebral function improving agent. n PREPARATION: The objective compound of formula I can be produced by reacting a compound of formula II (R 7 is H or amino protecting group) with a carboxylic acid of formula R 2 COOH. The compound of formula II is a new compound which can be produced by reacting a compound of formula III with a compound of formula IV, subjecting the resultant compound of formula V successively to reducing cyclization and amination, decarboxylating the obtained compound of formula VI and successively reacting with a compound of formula VII and a compound of formula VIII. n COPYRIGHT: (C)1991,JPO&Japio |