| abstract |
NEW MATERIAL:Compounds of formula 1 (R 1 and R 2 are H, lower alkyl or halogen; R 3 is lower alkyl, phenyl which may have lower alkyl as substituent, halogen-substituted lower alkyl, amino, lower alkylamino or lower alkanoylamino; R 4 is H, lower alkyl, nitro or amino; R 5 is H, hydroxyl or benzyloxy; R 6 is H or lower alkyl; n is 0 or 1) or salts thereof. n EXAMPLE: 1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-2-trifluoromethylbenzimidazole. n USE: Useful as an antibacterial agent, an antiviral agent, an anti-inflammatory agent, an antirheumatic, etc. n PREPARATION: For example, a compound of formula 2 is condensed with a compound of formula 3 in the presence of a catalyst and the resultant compound of formula 4 is reduced by the conventional method to obtain a compound of formula 5. The obtained compound of formula 5 is reacted with a compound of formula R 3a -COOH [R 3a is (halogenated)alkyl] and subjected to cyclization, thus obtaining the objective compound of formula 1 in which R 3 is R 3a , R 5 is OH; n=0. n COPYRIGHT: (C)1991,JPO&Japio |