| abstract |
NEW MATERIAL:The compound of formula I (R 1 is H, halogen, alkyl, alkenyl, etc.; R 2 is arylthio, alkylthio, cycloalkylsulfinyl, etc.; R 3 is H, methyl, alkyl, etc.; R 4 is H, alkyl or aralkyl; X is O or S; Y is O or S; etc.) or its salt. n EXAMPLE: 1-[(2-Acetoxyethoxy)methyl]-6-phenylthio-2-thiothymine. n USE: An antiviral agent exhibiting effective activity especially against retrovirus and having low toxicity to host cell. n PREPARATION: The compound of formula I can be produced by reacting a compound of formula II with an organic alkali metal (e.g. lithium diisopropylamide) and reacting the product with an electrophilic reagent (e.g. diaryl disulfide). n COPYRIGHT: (C)1991,JPO&Japio |