| abstract |
NEW MATERIAL:A compound of formula I [R 1 , R 2 are halogenoalkyloxy, alkyl thio, alkylsulfinyl; A is alkylene, carbonyl, single bond; Z is heterocyclic ring which may be substituted, NR 3 R 4 (R 3 , R 4 are H, alkyl which may bear heterocy clic ring, piperidyl which may be substituted), formula II (R 5 to R 7 are H, alkyl, cycloalkyl, or R 6 and R 7 incorporate together with N form heterocyclic ring which may be substituted, or R 5 and R 6 incorporate to give alkylene and R 7 is H] or its salt. n EXAMPLE: 4,5-Bis(4-methoxyphenyl)-2-guanidinothiazole. n USE: Antithrombotic, vasodilator, antiallergic, anti-inflammatory and 5- lipoxygenaso inhibitor. n PREPARATION: For example, the reaction of a compound of formula III (Q is eliminating group) with another compound of the formula: H-Z or its salt gives the compound of formula I or its salt. n COPYRIGHT: (C)1991,JPO&Japio |