| abstract |
NEW MATERIAL: A compound represented by formula I [R 6 is a 1-6C alkyl; X is CR 5 ; Y is CH; R 1 is NO 2 , NH 2 or NHCOR 8 (R 8 is a 1-6C alkyl); R 2 and R 3 are each H or a 1-6C alkyl which is substituted with (SO 3 H), piperazyl, piridyl, etc.), with the proviso that R 2 and R 3 are not simultaneously H; either one of R 4 and R 5 is H, a 1-6C alkyl or a 1-6C alkoxy and the other is H, a 1-6C alkyl or R 14 Z (R 14 is a 1-6C alkyl or phenyl; Z is O or S)]. n EXAMPLE: N-Methoxycarbonyl-N'-[2-(N'-cyano-N"-methylguanidino)-ethyl]-N"-(2- nitro-4-propylthiophenyl)guanidine. n USE: The antiparasitic medicinal composition is useful for exterminating intestinal parasites. n PREPARATION: For example, a compound of formula II is reacted with a compound of formula III in a reactive solvent to provide a compound of formula I. n COPYRIGHT: (C)1991,JPO |