| abstract |
PURPOSE: To prepare optically-active S-α-cyano-3-phnoxy-benzyl alcohol by reacting 3-phenoxybenzaldehyde with hydrogen cyanide in the presence of a specified catalyst. CONSTITUTION: Cyclo(D-phenylalanyl-D-histidine)dipeptide catalysts such as di- and poly-peptides having alanine (including portion thereof) are obtained from alanine, β-aminoalanine, β-phenylalanine, 3,4-dihydroxyphenylalanine, etc. Optionally substd. 3-phenoxybenzaldehyde is reacted with a hydrogen cyanide donor in the presence of the cyclo(D-phenylalanyl-D-histidine)dipeptide catalyst, to prepare optically active, optionally substd. S-α-cyano-3-phnoxybenzyl alcohol. |