http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H03236796-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_034bd2161632fd520429808a882d48af |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
filingDate | 1989-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d58ff1113e64015c541b868ade2c0ea9 |
publicationDate | 1991-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-H03236796-A |
titleOfInvention | Optical resolution method by enzyme |
abstract | PURPOSE: To efficiently obtain useful agricultural chemical in high yield by reacting a specific compound with a hydrolytic enzyme or enzyme mixture containing one or more kind of hydrolytic enzymes. n CONSTITUTION: A microorganism of the genus Candida such as Candida cylindracea strain is cultured to afford an asymmetric hydrolytic enzyme (A) such as lipase OF. Then methyl 2-substituted-2-benzyloxy-2-methyl-carboxylate (C) expressed by formula I (R is 2-12C saturated or unsaturated alkyl) and the above-mentioned enzyme A are added to a phosphoric acid buffer of pH5-8 to give the reaction mixture liquid (D). Then the ingredient D is subjected to reciprocating shaking reaction at about 30°C for 2-3 day to provide a reaction product (E). Then the ingredient E is controlled to about pH9 and extracted and purified with diethyl ether, etc., to provide an optically active ester expressed by formula II (asteric C is optically active carbon) and/or optically active carboxylic acid expressed by formula III in an optical resolution method. n COPYRIGHT: (C)1991,JPO&Japio |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9534525-A1 |
priorityDate | 1989-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.