abstract |
NEW MATERIAL:2,6-Dimethylmorpholino-N-phenylthiourea shown by formula I and N,N'-dimethyl-N,N'-bis(m-tolyl)thiuram disulfide shown by formula II. n USE: A therapeutic agent for liver diseases. n PREPARATION: 2,6-Dimethylmorpholine is made to react with phenyl isothiocyanate is a solvent such as toluene at room temperature to the boiling point of the solvent to give a compound shown by formula I. The compound shown by formula II is obtained by reacting N-methyl-m-toluidine with carbon disulfide and an aqueous solution of an alkali such as sodium hydroxide to give sodium N-methyl-N-(m-tolyl)dithiocarbamate, which is then oxidized with sodium hypochlorite at 20-50°C. n COPYRIGHT: (C)1991,JPO&Japio |