| abstract |
NEW MATERIAL:A compound expressed by formula I {R 1 is H or 1-6C alkyl; R 2 is R 1 , halogen, carboxyl, 1-6C alkoxy, carbamoyl, amino, nitro or sulfo, etc.; R 3 and R 4 are R 1 , 3-6C cycloalkyl or expressed by formula IV [Ar is (substituted)aryl or heteroaromatic ring having 5-6 membered ring containing 1-2N, etc.; (n) is 0-6]; with a proviso that R 4 ≠H}. n EXAMPLE: 1-(4-chlorophenyl)-1-N-methylthiocarbamoyl) methyl sulfoxide. n USE: Used as a medicine, especially as anti-hypertension agent having vasodilating action and antihypertensive action. n PREPARATION: A compound expressed by formula II (X is halogen or expressed by formula VIII, etc.) is allowed to react with thiourea expressed by formula V to obtain a compound expressed by formula III and then is reacted in an aqueous solution of alkali such as NaOH, followed by the reaction with a compound expressed by the formula: R 4 -Z (Z=X) to obtain a compound expressed by formula V. Then the compound of formula V is oxidized and allowed to react with CS 2 , CH 3 I and NH 3 , etc., in order to afford the objective compound expressed by formula I. n COPYRIGHT: (C)1991,JPO&Japio |