http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H03223260-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_324beb8b942a3a6ed1f1f576bcd76c45 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-28 |
| filingDate | 1989-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acffaca08d2c1b63dd346ce325f54689 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b40a646a79279ca8dee1e20e63ae2e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8768ac8c527b4b902e97fc2fc380f18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e5e42b8b91a45789e8bd1d579956ef3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ac466a2f81a66295e706e7b0c129c44 |
| publicationDate | 1991-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H03223260-A |
| titleOfInvention | Benzimidazole derivative and its preparation and anti-ulcer agent containing the same |
| abstract | NEW MATERIAL:A benzimidazole of formula I (R 1 and R 2 are mutually independently H or lower alkyl). n EXAMPLE: 2-(2-Methylaminobenzylsulfinyl)benzimidazole. n USE: Useful as an antiulcer agent. The compound exhibits a gastric acid secretion- inhibiting action based on the excellent H + +K + ATPase-inhibiting action thereof. n PREPARATION: A 2-mercaptoimidazole of formula II is subjected to a reaction with a 2-aminobenzyl compound of formula III (X is a reactive group) preferably in the presence of an alkaline agent such as sodium hydroxide in a solvent such as toluene at the room temperature to the refluxing temperature of the solution to prepare a compound of formula VI. The compound of the formula VI is oxidized with an oxidizing agent such as hydrogen peroxide in a solvent such as chloroform at -30°C to 50°C to provide the compound of formula I. n COPYRIGHT: (C)1991,JPO&Japio |
| priorityDate | 1989-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.