| abstract |
NEW MATERIAL:An aminonaphthalene compound expressed by formula I [B is 5-7 membered aza heterocyclic group; A is direct bond, hydrocarbon residue, oxo, hydroxyimino, divalent or trivalent aliphatic hydrocarbon residue; full line and dotted line each represent single bond and double bond (provided that when A represents direct bond, it is single bond); R 2 and R 3 are H or hydrocarbon residue and R 1 and R 2 form cyclic amino together with adjacent N; (p) is 1 or 2] and slat thereof. n EXAMPLE: 1-Acetyl-4-[(4-dimethylamino-1-naphthyl)carbonyl]piperidine. n USE: Cerebral edema treating agent, brain nerve cell protecting agent, cholin esterase inhibiting agent and brain function improving agent. n PREPARATION: A compound expressed by formula II (R 7 is acyl, etc.; X is halogen; (m) is 0-2) is subjected to a reaction with a compound expressed by formula III (Y is halogen) and then made to react with a compound expressed by formula IV to provide the compound expressed by formula V which is one of the compound expressed by formula I. n COPYRIGHT: (C)1991,JPO&Japio |