| abstract |
NEW MATERIAL:A compound of formula I [R 1 and R 2 are each α-amino acid side chain of alanine, valine, (iso)leucine, methionine, tryptophan, phenylalanine, proline, glycine, serine, threonine, cysteine, asparagine, glutamine, lysine, histidine, arginine, aspartic acid or glutamic acid]. n EXAMPLE: Cyclic monothio-L-phenylalanyl-L-phenylalanine. n USE: An intermediate for analgesics, bactericidal agents, platelet aggregation inhibitory agents, etc., and a catalyst, etc. n PREPARATION: A monothiodipeptide ester derivative of formula II [R 3 is alicyclic alkyl, aryl, aralkyl or alicyclic compound; the absolute configuration of asymmetric carbon atom directly bound to R 1 and R 2 is (L-, L), (L-, D-), (D-, D-) or (D-, L-)] is heat-reacted in a mixed solvent comprising a water-miscible organic solvent and a salty buffer solution of pH5-10. n COPYRIGHT: (C)1991,JPO&Japio |