| abstract |
NEW MATERIAL:An anticancer antibiotic M143-37F11 expressed by the formula. n USE: A medicine effective in Ehrlich solid cancer. The above-mentioned antibiotic has low toxicity and stronger anticancer activity and useful to remedy for human cancer. n PREPARATION: An antibiotic M143-37F11 producing bacterium belonging to Streptoverticillium is cultured and anticancer antibiotic M143-37F11 is collected from the culture medium. As a nutritious source, a material usable as a nutri tious source of actinomyces, e.g. peptone, meat extract, corn, glucose or ammo nium nitrate which is put on the market is used. In the mass production of the aimed antibiotic, liquid culture is preferably used and culture temperature is normally 27-32°C. The aimed antibiotic is obtained from the culture medium by extracting the antibiotic from cultured filtrate with a water miscible organic solvent such as ethyl acetate in weakly acidic conditions. The aimed antibiotic can be also purely collected by combining absorption chromatography, etc. n COPYRIGHT: (C)1991,JPO&Japio |