| abstract |
Disclosed herein are pentapeptide derivatives of the formula X-NR<1>-CH(R<2>)-C(W<1>)-NH-CR<3>(R<4>)-C(W<2>)-NR<5>-CH[CH2C(O)-Y]C(W <3>)-NH-CR <6>- [C R<7> (R <8>) -C OO H] -C(W<4>)-NH-CR<9>(R<1><0>)-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R<1> is hydrogen, alkyl or phenylalkyl, R<2>, R<4> and R<1><0> are selected from amino acid or derived amino acid residues, R<3>, R<5>, R<6>, R<7>, R<8> and R<9> are hydrogen or alkyl or R<7> and R<8> are joined to form a cycloalkyl, W<1>, W<2>, W<3> and W<4> are oxo or thioxo, Y is, for example, an alkoxy or a mono or disubstituted amino, and Z is a terminal group, for example, COOH or CH2OH. The derivatives are useful for treating herpes infections. |