| abstract |
NEW MATERIAL: A compd. of formula I [R 1 is H or methyl; R 2 is ethyl, propyl, isopropyl, imidazol-2-yl, pyrazol-3-yl, etc.; R 3 is isobutyl, benzyl, etc.; R 4 is OH or NH 2 ; R 5 is alkyl, alkenyl, aryl, etc.; n is 0-6; A is formula II (R 6 is phenyl, naphtyl, etc.; R 7 is H, alkoxycarbonylalkyl, etc.), Y-Z (Y is phenylglycine, phenylalanine, etc., linked with Z at the N terminal; Z is H, acryl)]. 6r:(2R or S,3S)3-(Boc-DProPhe-HisNH)-1,4dicyclohexyl2-butanol. n USE: A prophylactic agent for hypertension and cardiac insufficiency. n PROCESS: For example, a compd. of formula III is reacted with a compd. of formula IV or its activated derivative to obtain a compd. of formula I wherein R 4 is OH. n COPYRIGHT: (C)1991,JPO |