| abstract |
PURPOSE: To obtain a preventive and curing agent for chronic neurodegenerative disease and suitable for preventive of denaturation of neuron by containing an antagonist against an N-methyl-D-aspartate(NMDA)-receptor complex material. CONSTITUTION: This preventive and curing agent contains an antagonist against an NMDA-receptor complex material or its biologically permissible salt, e.g. 2-amino-7-phosphonoheptanoic acid, (±)10,11-dihydro-5-methyl-5H-dibenzo-[a,d]- cycloheptene-5,10-imine or kynurenic acid. The agent is effective for suppression of degeneration of dopamine neuron, especially degeneration induced by a neurotoxin 1-methyl-4-phenyl-pyridinium ion and is applied to Parkinson's disease, Alzheimer's disease, Huntington's disease, etc. |