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filingDate 1989-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c864d36e0e97fa839261af9da3c5817f
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publicationDate 1991-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H0320287-A
titleOfInvention Production of beta-lactam compound
abstract PURPOSE: To obtain the subject compound, having a silyl ether group at the 4-position and useful as an intermediate convertible into various derivatives by reducing a specific β-lactam compound with an organometallic compound in an organic solvent. n CONSTITUTION: An N-sulfonyl β-lactam compound expressed by formula I (R represents OH-protecting group; R 2 to R 4 represent 1-6C alkyl, phenyl or aralkyl; X 1 represents halogen) [example; 3-(1-tert.-butyldimethyl-silyloxyethyl)-1- chlorosulfonyl-4-trimethylsilyloxy-ozetidin-2-one] is reduced in an organic solvent (example; toluene) with an organometallic compound expressed by the formula R 5 -M [R 5 represents (substituted) alkyl, (substituted) phenyl or aralkyl; M represents (halogeno)metal] (preferably phenylmagnesium chloride or benzyl- magnesium chloride) preferably at -30°C to ambient temperature the objective compound expressed by formula II. n COPYRIGHT: (C)1991,JPO&Japio
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Total number of triples: 26.