| abstract |
NEW MATERIAL: A pure lissoclinamide 7. n USE: Therapeutic agents for cancer and related diseases. n PROCESS: For example, a cleared ascidian such as Lissoclinum patella or Lissoclinum bistratum is homogenized with an alcohol/hydrocarbon solution. The homogenate is filtered and the filtrate is extracted with IM sodium nitrate. The aqueous layer is extracted with CHCl 3 . The extract is concentrated to give an oil, which is then hydrolyzed in 6M HCl and mercaptane. The hydrolyzate is concentrated by evaporation and the residue is purified by chromatography on a column to obtain lissoclinamide 7 comprising a cyclic hexapeptide. n COPYRIGHT: (C)1991,JPO |