| abstract |
NEW MATERIAL:A compound expressed by formula I (m and n are 1 or 2; R 1 and R 2 are H, lower alkyl, lower alkoxy, lower alkylsulfenyl, NO 2 , NH 2 , methanesulfonyloxy or halogen; A 1 is lower alkanesulfonyl, halo-lower alkanesulfonyl, substituted benzenesulfonyl or halo-lower alkoxyl; A 2 is H, lower alkanesulfonyl, halo-lower alkanesulfonyl or lower alkyl). n EXAMPLE: 2-Trifluoromethanesulfonylamino-4,5-diphenylthiazole. n USE: A nonsteroidal anti-inflammatory agent. n PREPARATION: A compound expressed by formula V is mixed with a compound expressed by formula IV in a suitable solvent (e.g. methanol, ethanol or THF) at ambient temperature or while being heated to afford the compound expressed by formula I. n COPYRIGHT: (C)1991,JPO&Japio |