| abstract |
NEW MATERIAL:A compound expressed by formula I [A is trihalogenomethylphenyl, formula II (R 1 is lower alkyl or lower alkoxy) or formula III (R 2 and R 3 are H, acyl, aralkyl or R 2 and R 3 form lower alkylene together); B is di-lower alkylamino or heterocyclic group which may have substituent group and contain at least one N] and salt thereof. n EXAMPLE: 1-[2,3-Bis(benzyloxy)phenyl]-2-methyl-3-(piperidine-1-yl)propane-1-one. n USE: The compound expressed by formula I and salt thereof have 5-lipoxygenase inhibiting activity and antileukotriene action and are useful for treatment of allergic disease, asthma, skin disease and ischemic heart disease. n PREPARATION: For example, a vinylketone derivative expressed by formula IV (F is formula V; R 8 and R 9 are acyloxy or aralkyloxy) is reacted with a desired amine derivative under normal Michael reaction conditions to provide the compound expressed by formula I. n COPYRIGHT: (C)1991,JPO&Japio |