| abstract |
NEW MATERIAL: Mevinic acid derivative of formula I [Z means formula II (m is 0-3), or formula III; R means alkyl; R 1 means alkyl, alkoxy, amino, etc., R 2 means H, ammonium, alkyl]. n EXAMPLE: [1S-[1α,3β,7β,8β(2S*, 4S*),8α,β]]-2,2-dimethylbutyric acid decahydro-3- hydroxyl-1,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1- naphthalenylester. n USE: An antiarteriosclerosis agent, an antihyperlipidemia agent, a mycotic depressor for plants, a plasma high density lipoprotein cholesterol ascending agent, an antichoresteremia agent. n PROCESS: For example, a compound of formula VII can be obtained from a compound of formula IV (Pro 1 , Pro 2 is protecting groups of OH; Pro 3 is alkyl), via a compounds of formula V and VI, and by oxidizing the compound of formula VII a compound of formula VIII which is one of compounds of formula I can be obtained. n COPYRIGHT: (C)1991,JPO |